陳宏斌

北京大學人民醫院

北京大學人民醫院,檢驗科,研究員,全國細菌耐藥監測學術委員會青年委員會副主任委員,中國醫療保健國際交流促進會臨床微生物與感染分會常務委員,北京微生物學會理事,北京藥理學會抗感染藥理專業委員會青年委員。主要從事臨床微生物學檢驗、細菌耐藥監測及細菌耐藥機制研究。 曾獲第五屆北京大學人民醫院學術新星三等獎。以第一作者發表SCI文章13篇,總影響因子48分,以第一作者發表中文文章7篇。

 

主持科研課題:

  1. 國家自然科學基金面上項目(項目批準號:81471990)、

  2. 國家自然科學基金青年基金(項目批準號:31100106)、

  3. 北京市自然科學基金(項目批準號:7143185

  4. 北京大學人民醫院研究與發展基金(項目批準號:RDB2013-09)。

 

受教育經歷

2007/09-2010/07,北京協和醫學院,北京協和醫院,醫學碩士

1999/09-2004/07,四川大學華西醫學中心,臨床醫學院,醫學學士同時修第二專業軟件工程


研究工作經歷

2010/08-2012/04,北京協和醫院檢驗科,實習研究員

2012/05-2013/08,北京大學人民醫院檢驗科,實習研究員

2013/09-2017/08,北京大學人民醫院檢驗科,助理研究員

2017/10-2018/10 ,University College London訪問學者

2017/09-至今,   北京大學人民醫院檢驗科,研究員

 

主要論著

發表文章19篇,其中以第一作者在SCI期刊發表論文13,總影響因子48分。

  1. 期刊論文:

  2. Hongbin Chen, Qi Wang, Yuyao Yin, Shuguang Li, Dengke Niu, Hui Wang. Genotypic variations between wild-type and small colony variants of staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. Int J Antimicrob Agents. 2018, 51(4):655-658. (SCI IF=4.415)

  3. Hongbin Chen, Xiong Z, Liu K, Li S, Wang R, Wang X, Zhang Y, Wang H. Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance. Int J Antimicrob Agents. 2016, 47(5):362-7. (SCI IF=4.415)

  4. Hongbin Chen, Wang Z, Li H, Wang Q, Zhao C, He W, Wang X, Zhang F, Wang H. In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China. Jpn J Infect Dis. 2015;68(4):263-7. (SCI IF=1.14)

  5. Hongbin Chen, Xi Yang, Qi Wang, et al. Insights on Evolution of Virulence and Resistance from the Wholegenome Analysis of a Predominant Methicillin-resistant Staphylococcus aureus Clone Sequence Type 239 in China. CHINESE SCI BULL. 2014, 59(11):1104-1112. (SCI IF=1.319)

  6. Hongbin Chen, Qing Yang, Rong Zhang, et al. In-vitro antimicrobial activity of a novel oxazolidinone tedizolid and other comparators against Staphylococcus aureus and linezolid-resistant Gram-positive pathogens: a multicenter study in China. Int J Antimicrob Agents, 201444(3):276-7. (SCI IF=4.415)

  7. Hongbin Chen, Weiyuan Wu, Ming Ni, Yingmei Liu, Jixia Zhang, Fei Xia, Wenqiang He, Qi Wang, Zhanwei Wang, Bin Cao, Hui Wang*. Linezolid-resistant clinical isolates of enterococci and staphylococcus cohnii from a multicentre study in china: Molecular epidemiology and resistance mechanisms. Int J Antimicrob Agents, 2013;42:317-321. (SCI IF=4.415)

  8. Wenqiang He*, Hongbin Chen*, Chunjiang Zhao, Feifei Zhang,Henan Li, Qi Wang, Xiaojuan Wang, Hui Wang*. Population structure and characterisation of Staphylococcus aureus from bacteraemia at multiple hospitals in China: association between antimicrobial resistance, toxin genes and genotypes. Int J Antimicrob Agents, 2013, 42(3): 211-219. SCI IF=4.415, 并列第一作者)

  9. Hongbin Chen, Yali Liu, Chunjiang Zhao, Di Xiao, Jianzhong Zhang, Feifei Zhang, Minjun Chen, Hui Wang*. Comparative Proteomics-Based Identification of Genes Associated with Glycopeptide Resistance in Clinically Derived Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Strains. Plos One 2013, 8(6):e66880. (SCI IF=3.73)

  10. Hongbin Chen, Yudong Liu, Wenjia Sun, et al. The incidence of heterogeneous vancomycin-intermediate Staphylococcus aureus correlated with increase of vancomycin MIC. Diagn Microbiol Infect Dis. 2011, 71(3):301-303. (SCI IF=2.451)

  11. Hongbin Chen, Hui Wang, Yudong Liu, et al. Rapid change of methicillin-resistant Staphylococcus aureus clones in a tertiary care hospital of China over a fifteen-year period. Antimicrob Agents Chemother, 2010, 54: 1842-1847. (SCI IF=4.716)

  12. Wenjia Sun*, Hongbin Chen*, Yudong Liu, et al. Prevalence and characterization of heteroresistant vancomycin-intermediate resistant Staphylococcus aureus (hVISA) isolates from 14 cities in China. Antimicrob Agents Chemother, 2009 53: 3642-3649. (SCI IF=4.716,并列第一作者)

  13. Hong Yang*, Hongbin Chen*, Qiwen Yang, et al. High Prevalence of plasmid-mediated quinolone Resistance Genes qnr and aac(6`_)-Ib-cr in clinical isolates of Enterobacteriaceae from nine teaching hospitals in China. Antimicrob Agents Chemother, 2008, 52: 4268–4273. (SCI IF=4.716,并列第一作者)

  14. Henan Li*, Chunjiang Zhao*, Hongbin Chen*, et al. Identification of gene clusters associated with host adaptation and antibiotic resistance in Chinese Staphylococcus aureus isolates by microarray-based comparative genomics. Plos One. 2013, 8(1):e53341.SCI IF=3.73, 并列第一作者)

  15. 陳宏斌,趙春江,王輝,. 2011年中國13家教學醫院院內獲得性細菌耐藥性分析. 中華內科雜志. 20133月第52卷第3.

  16. 陳宏斌,王輝,孫聞嘉,. 2007年中國14個城市分離的異質性萬古霉素中介耐藥的耐甲氧西林金黃色葡萄球菌分子特征. 中華檢驗醫學雜志. 2009, 32 (11): 1223-1227.

  17. 陳宏斌,王輝. 萬古霉素敏感性下降的金黃色葡萄球菌研究進展. 中華檢驗醫學雜志. 2009, 32(11): 1214-1217.

  18. 陳宏斌,楊啟文,陳民鈞,. 頭孢噻利對臨床常見細菌體外抗菌活性的多中心研究. 中國感染與化療雜志. 2011, 11(4): 256-263.

  19. 陳宏斌, 張小江, 趙穎, . 衛生部全國細菌耐藥監測網(Mohnarin) 2009年度報告: ICU來源細菌耐藥監測. 2011, 27(7): 483-489.

  20. 陳宏斌 黃加銘 楊青等. 43株利奈唑胺耐藥葡萄球菌耐藥機制研究. 中華檢驗醫學雜志, 2016,39(11):848-851.

  21. 陳宏斌;趙春江;王輝等. 2007-2013年醫院內獲得性肺炎病原菌分布及其耐藥性分析. 中華醫院感染學雜志, 2017, (01) 1-7.


 

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